Sparstolonin B prevents lumbar intervertebral disc degeneration through toll like receptor 4, NADPH oxidase activation and the protein kinase B signaling pathway
نویسندگان
چکیده
منابع مشابه
MyD88-dependent Toll-like receptor 4 signal pathway in intervertebral disc degeneration
Lower back pain (LBP) is a common and remitting problem. One of the primary causes of LBP is thought to be degeneration of the intervertebral disc (IVD). The aim of the present study was to investigate the role of the myeloid differentiation primary-response protein 88 (MyD88)-dependent Toll-like receptor 4 (TLR4) signal pathway in the mechanism of IVD degeneration. IVD nucleus pulposus cells i...
متن کاملincidence of microscopic lumbar intervertebral disc calcification and its correlation to endplate degeneration type and disc histopathologic angiogensis
چکیده ندارد.
15 صفحه اولEndotoxin induces toll-like receptor 4 expression in vascular smooth muscle cells via NADPH oxidase activation and mitogen-activated protein kinase signaling pathways.
OBJECTIVE Toll-like receptor 4 (TLR4) plays a major role mediating endotoxin-induced cellular inflammation and regulates vascular smooth muscle cell (VSMC) proliferation, which is related to atherogenesis and restenosis. This study was conducted to investigate the mechanisms involved in lipopolysaccharide (LPS)-induced TLR4 expression in VSMCs. METHODS AND RESULTS Stimulation of human aortic ...
متن کاملNADPH Oxidase Activation and Mitogen-Activated Protein Kinase Signaling Pathways Endotoxin Induces Toll-Like Receptor 4 Expression in Vascular Smooth Muscle Cells via
Feng-Yen Lin, Yung-Hsiang Chen, Jen-Sung Tasi, Jaw-Wen Chen, Tung-Lin Yang, Hsiao-Jung NADPH Oxidase Activation and Mitogen-Activated Protein Kinase Signaling Pathways Endotoxin Induces Toll-Like Receptor 4 Expression in Vascular Smooth Muscle Cells via Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2006 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas,...
متن کاملCalcineurin B stimulates cytokine production through a CD14-independent Toll-like receptor 4 pathway
The calcineurin B subunit (CnB) is the regulatory subunit of Cn, a Ca(2+)/calmodulin-dependent serine/threonine protein phosphatase. In this study, we demonstrate that extracellular CnB was effectively internalized through a CD14-independent Toll-like receptor 4 (TLR4) pathway, which led to the phosphorylation of nuclear factor (NF)-kappa-B inhibitor alpha (IκB-α) and upregulation of pro-inflam...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2017
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2017.7966